| lw | TW | Artist | Title | Label | TW | lw | Move | |
| 3 | 1 | TIMBALAND | Say Something f/Drake | Mosley/Interscope | 3936 | 3691 | 245 | |
| 1 | 2 | LUDACRIS | How Low | DTP/Def Jam/IDJMG | 3848 | 4056 | -208 | |
| 2 | 3 | TREY SONGZ | Say Aah | Songbook/Atlantic | 3707 | 3711 | -4 | |
| 8 | 4 | ROBIN THICKE | Sex Therapy | Star Trak/Interscope | 3501 | 3048 | 453 | |
| 7 | 5 | ALICIA KEYS | Try Sleeping With A Broken… | J/RMG | 3232 | 3125 | 107 | |
| 4 | 6 | YOUNG MONEY | Bedrock f/Lloyd | YM/CM/Universal Motown | 3152 | 3522 | -370 | |
| 5 | 7 | MELANIE FIONA | It Kills Me | SRC/Universal Motown | 3035 | 3349 | -314 | |
| 6 | 8 | SNOOP DOGG | I Wanna Rock | DS/Priority/Capitol | 2822 | 3226 | -404 | |
| 9 | 9 | JAY-Z | On To The Next One | Roc Nation | 2785 | 2614 | 171 | |
| 10 | 10 | MARY J. BLIGE | I Am | Geffen/Interscope | 2665 | 2424 | 241 | |
| 12 | 11 | USHER | Hey Daddy (Daddy’s Home) | LaFace/JLG | 2574 | 2208 | 366 | |
| 11 | 12 | TREY SONGZ | I Invented Sex f/Drake | Atlantic | 2004 | 2212 | -208 | |
| 13 | 13 | WAKA FLOCKA FLAME | O Let’s Do It | 1017 Brick/Warner Bros. | 1999 | 1964 | 35 | |
| 14 | 14 | GUCCI MANE | Lemonade | BS/Asylum/Warner Bros. | 1820 | 1808 | 12 | |
| 17 | 15 | ROSCOE DASH | All The Way Turnt Up | Musicline/Interscope | 1784 | 1520 | 264 | |
| 19 | 16 | MONICA | Everything To Me | J/RMG | 1714 | 1349 | 365 | |
| 18 | 17 | YO GOTTI | Women Lie f/Lil Wayne | Polo Grounds/J/RMG | 1539 | 1479 | 60 | |
| 20 | 18 | 50 CENT | Do You Think About Me | Shady/After/Interscope | 1521 | 1316 | 205 | |
| 15 | 19 | BIRDMAN | Money To Blow f/Lil Wayne | Universal Motown | 1387 | 1704 | -317 | |
| 21 | 20 | TREY SONGZ | Neighbors Know My Name | Songbook/Atlantic | 1367 | 991 | 376 | |
| 22 | 21 | YOUNG MONEY | Steady Mobbin’ f/Gucci Mane | YM/CM/Universal Motown | 1144 | 954 | 190 | |
| 16 | 22 | RIHANNA | Hard f/Jeezy | Def Jam/IDJMG | 1135 | 1548 | -413 | |
| 23 | 23 | SADE | Soldier Of Love | Epic | 1007 | 949 | 58 | |
| 24 | 24 | OMARION | Speedin | Starrworld/MWorks/Capitol | 999 | 911 | 88 | |
| 25 | 25 | MARIAH CAREY | Up Out My Face | Island/IDJMG | 984 | 910 | 74 | |
| 27 | 26 | JAHEIM | Ain’t Leavin Without You | Atlantic | 875 | 883 | -8 | |
| 28 | 27 | PARTY BOYZ | Flex | Hitz Committee/Battery | 841 | 845 | -4 | |
| 26 | 28 | JAY-Z | Empire State Of Mind f/A. Keys | Roc Nation | 825 | 891 | -66 | |
| 32 | 29 | USHER | Lil’ Freak f/Nicki Minaj | LaFace/JLG | 787 | 643 | 144 | |
| 34 | 30 | DONDRIA | You’re The One | So So Def/Malaco | 760 | 638 | 122 | |
| 31 | 31 | BIRDMAN | 4 My Town (Play Ball) f/Drake | CM/Universal Motown | 716 | 685 | 31 | |
| 33 | 32 | BONE | Homegurl (He Gotta) | Citi US Ent/IDJMG | 701 | 642 | 59 | |
| 38 | 33 | B.O.B | Nothin’ On You f/Bruno Mars | Rebel Rock/GH/Atlantic | 679 | 544 | 135 | |
| 36 | 34 | TEAIRRA MARI | Sponsor f/Gucci Mane & Soulja | For/Asylum/Warner Bros. | 628 | 623 | 5 | |
| 29 | 35 | USHER | Papers | LaFace/JLG | 591 | 782 | -191 | |
| 45 | 36 | RIHANNA | Rude Boy | Def Jam/IDJMG | 576 | 301 | 275 | |
| 39 | 37 | MAXWELL | Fistful Of Tears | Columbia | 515 | 505 | 10 | |
| 37 | 38 | 50 CENT | Baby By Me | Interscope | 490 | 565 | -75 | |
| 42 | 39 | TRINA | Million Dollar f/Diddy&Keri H. | Slip-N-Slide/EMI/Capitol | 483 | 422 | 61 | |
| 30 | 40 | PLIES | Medicine f/Keri Hilson | Big Gates/SNS/Atlantic | 443 | 751 | -308 | |
Ludacris loses the #1 Spot…Top 40 Urban Radio Chart with Spins Week Ending 2.21.2010
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